Our comprehensive guide hospitals information helps you quickly locate a hospital anywhere in the world. Our database contains in excess of 16,000 hospitals, making it one of the best places to find information on the hospital you are searching for. To assist you with locating a hospital, you can refine your search by selecting the country in which the hospital is located and choose to search by either hospital name, city/town or state/county.

 Home>> Clolar (clofarabine)

Clolar (clofarabine)

General Information

Clolar (clofarabine) is an anti-neoplastic purine nucleoside analog used to treat lymphoblastic leukemia . The drug acts as an anti-metabolite, interfering with DNA replication. In addition, the drug appears to disrupt the integrity of the mitochondrial membrane, releasing pro-apoptotic mitochondrial proteins, cytochrome C and apoptosis-inducing factor, activating pathways of programmed cell death. In these ways Clolar exerts a cytotoxic effect on both rapidly dividing and quiescent cancer cells.

Clolar is specifically indicated to treat acute lymphoblastic leukemia (ALL) in pediatric patients ages 1-21, whose disease has relapsed or beecome refractory after at least two prior treatment regimens.

Clolar is administered as an intravenously, with a recommended dosage of 52 mg/m2 via 2-hour infusion dialy for 5 days, with cycle repeats every 2-6 weeks once organ function has returned to baseline.


Additional Information

For additional information regarding Clolar or acute lymphoblastic leukemia, please visit the Genzyme Oncology web page.


Clinical Results

FDA approval of Clolar was based on a pair of clinical trials, involving a total of 66 pediatric ALL patients. The first was a open-label, dose-escalation, noncomparative study, which enrolled a total of 17 pediatric ALL patients . Subjects received escalating doses of the drug ranging from 11.25 mg/m2 to 70 mg/m2, daily for 5 days. 9 of the 17 received the recommended dose of 52 mg/m2. Among all patients 2 complete and 2 patial responses were observed. Dose limiting toxicities, including reversible hyperbilirubinemia and elevated transaminase levels and skin rash, were observed at 70 mg/m2, leading to the choice of 52 mg/m2 as the optimum dose.

The second study was a single arm, open label study which enrolled 49 pediatric ALL patients. Subjects in this study received up to sequential cycles at the recommended dose (52 mg/m2 x 5 days), with no dose escalation. Efficacy was observed in the trial's primary endpoint, the overall rate of response. Specifically, there were 6 completer responses (CR; 12.2%), 4 complete responses which did not also demonstrate platelet recovery (CRp; 8.2%), and 5 partial responses (PR; 10.2%), for a total response rate of 30.6%. Among the 9 responding patients who did not undergo bone marrow transplant following treatment, response durations were as follows: 43, 50, 82, 93+ and 160+ days for CR subjects, 32 days for one CRp subject, and 7, 16, and 21 days for PR subjects.


Mechanism of Action

Clolar disrupts DNA synthesis and causes fatal replication errors through the disruption of several intracellular syntetic pathways. Specifically, the drug depletes deoxynucleotide triphosphate pools through the inhibition of ribonucleotide reductase, and causes termination of DNA chain elongation through incorporation into the DNA strand and competitive inhibition of DNA polymerases. Furthermore, the drug has been shown to disrupt mitochondrial membrane intergrity, possibly through disruption of mitochondrial DNA synthesis. Disruption of mitochondrial integrity leads to the release of the pro-apoptotic mitochondrial proteins, cytochrome C and apoptosis-inducing factor, which activate programmed cell death pathways.


Literature References

Side effects

Adverse events associated with the use of Clolar may include (but are not limited to) the following:


  • Febrile neutropenia
  • Systemic Inflammatory Response Syndrome (SIRS)
  • Vomiting
  • Nausea
  • Diarrhea
  • Pyrexia
  • Rigors
  • Abdominal Pain
  • Fatigue
  • Tachycardia
  • Anorexia Additionally, animal models have demostrated teratogenic potential in pregnant women. Human embryo toxicity has not been investigated, but the likelyhood of risk to the fetus is very high, and pregnancy should be avoided while receiving Clolar.

Treatment

Lymphoblastic Leukemia

Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Auryxia (Ferric citrate) Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Humira (adalimumab) Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Restasis (cyclosporine ophthalmic emulsion) Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Ravicti (glycerol phenylbutyrate) Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Adcetris (brentuximab vedotin) Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Epclusa (sofosbuvir and velpatasvir) Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Infasurf Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Cinqair (reslizumab) Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Tafinlar (dabrafenib) Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Krystexxa (pegloticase) Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Redux (dexfenfluramine hydrochloride) Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Arixtra Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Cimetidine Hydrochloride Oral Solution Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Fycompa (perampanel) Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Adderall XR Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Cosentyx (secukinumab) Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Qsymia (phentermine + topiramate extended-release) Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Arimidex (anastrozole) Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Afstyla (Antihemophilic Factor (Recombinant), Single Chain) Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print PREVEN ; Emergency Contraceptive Kit Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Verdeso (desonide) Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Amevive (alefacept) Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Aplenzin (bupropion hydrobromide) Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Orkambi (lumacaftor and ivacaftor) Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Cabometyx (cabozantinib) Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Trovan Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Rhinocort Aqua Nasal Spray Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Axona (caprylidene) Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Dynabac Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Curosurf Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Otiprio (ciprofloxacin otic suspension) Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Pepcid Complete Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Alimta (pemetrexed for injection) Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Intron A (Interferon alfa-2b, recombinant) Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Azor (amlodipine besylate; olmesartan medoxomil) Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Zofran Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print OxyContin (oxycodone HCl controlled-release) Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Onzetra Xsail (sumatriptan nasal powder) Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Atacand (candesartan cilexetil) Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print RenaGelRenagel (sevelamer hydrochloride)