Our comprehensive guide hospitals information helps you quickly locate a hospital anywhere in the world. Our database contains in excess of 16,000 hospitals, making it one of the best places to find information on the hospital you are searching for. To assist you with locating a hospital, you can refine your search by selecting the country in which the hospital is located and choose to search by either hospital name, city/town or state/county.

 Home>> Folotyn (pralatrexate injection)

Folotyn (pralatrexate injection)

General Information

Folotyn contains pralatrexate, a small molecule chemotherapeutic agent that inhibits dihdrofolate reductase (DHFR). DHFR is a folate dependent enzyme involved in the building of DNA and other processes. Folotyn is transported into tumor cells via the reduced folate carrier (RFC-1). This injectable, small molecule, cytotoxic agent has been designed for improved transport into tumor cells and greater intracellular drug retention.

Folotyn is specifically indicated for the treatment of patients with relapsed or refractory peripheral T-cell lymphoma.

Folotyn is supplied as a solution designed for intravenous administration. The recommended dose is 30 mg/m2 administered as an intravenous (IV) push over 3-5 minutes via the side port of a free flowing 0.9% Sodium Chloride Injection, USP IV line once weekly for 6 weeks in 7 week cycles until progressive disease or unacceptable toxicity.

Vitamin Supplementation
Patients should take low-dose (1.0-1.25 mg) oral folic acid on a daily basis. Folic acid should be initiated during the 10-day period preceding the first dose of Folotyn, and dosing should continue during the full course of therapy and for 30 days after the last dose of Folotyn. Patients should also receive a vitamin B12 (1 mg) intramuscular injection no more than 10 weeks prior to the first dose of Folotyn and every 8-10 weeks thereafter.


Additional Information

For additional information regarding Folotyn or peripheral T-cell lymphoma, please visit the Folotyn web page.


Clinical Results

FDA Approval
The FDA approval of Folotyn was based on the results of an open-label, single-arm, multicenter, international trial. The trial enrolled 111 subjects with relapsed of refractory PTCL. The subjects received Folotyn at 30 mg/m2 once weekly by IV push over 3-5 minutes for 6 weeks in 7-week cycles until disease progression or unacceptable toxicity. Of the 111 subjects treated, 109 were evaluable for efficacy. The primary efficacy endpoint was overall response rate (complete response, complete response unconfirmed and partial response) as assessed by International Workshop Criteria (IWC). The key secondary efficacy endpoint was duration of response. Response assessments were scheduled at the end of cycle 1 and then every other cycle (every 14 weeks). The overall response rate was 27% and the median duration of response was 287 days (9.4 months). Of the responders, 66% responded within cycle 1. The median time to first response was 45 days.


Mechanism of Action

Folotyn contains pralatrexate, an antineoplastic folate analog metabolic inhibitor that competitively inhibits dihydrofolate reductase. It is also a competitive inhibitor for polyglutamylation by the enzyme folylpolyglutamyl synthetase. This inhibition results in the depletion of thymidine and other biological molecules the synthesis of which depends on single carbon transfer.


Literature References

Side effects

Adverse events associated with the use of Folotyn may include, but are not limited to, the following:

  • mucositis
  • thrombocytopenia
  • nausea
  • fatigue
  • anemia
  • constipation
  • pyrexia
  • edema
  • cough


Treatment

peripheral T-cell lymphoma

Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Rhinocort Aqua Nasal Spray Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Rozerem (ramelteon) Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Pramipexole Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Oxytrol (oxybutynin transdermal system) Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Retavase (reteplase) Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Proleukin Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Nplate (romiplostim) Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Accretropin (somatropin rDNA Original) Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Stivarga (regorafenib) Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Oral Cytovene Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Belviq (lorcaserin hydrochloride) Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Revlimid (lenalidomide) Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Cinqair (reslizumab) Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Zoloft (sertraline HCl) Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Azor (amlodipine besylate; olmesartan medoxomil) Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print BeneFIX (coagulation Factor IX (recombinant)) Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Orkambi (lumacaftor and ivacaftor) Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Prempro Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Oxtellar XR (oxcarbazepine extended release) Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print RenaGelRenagel (sevelamer hydrochloride) Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Photodynamic Therapy Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print AndroGel testosterone gel Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Lynparza (olaparib) Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Aplenzin (bupropion hydrobromide) Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Alvesco (ciclesonide) Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Zuplenz (ondansetron oral soluble film) Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Nuplazid (pimavanserin) Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Cialis (tadalafil) Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Pentoxifylline Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Kadcyla (ado-trastuzumab emtansine) Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Children's Motrin Cold Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Pradaxa (dabigatran etexilate mesylate) Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Livalo (pitavastatin) Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Rectiv (nitroglycerin) ointment 0.4% Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Claritin-D 24 Hour Extended Release Tablets (10 mg loratadine, 240 mg pseudoephedrine sulfate) Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Prevpac Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Afinitor (everolimus) Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Priftin Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Crestor (rosuvastatin calcium) Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Altabax (retapamulin)