Our comprehensive guide hospitals information helps you quickly locate a hospital anywhere in the world. Our database contains in excess of 16,000 hospitals, making it one of the best places to find information on the hospital you are searching for. To assist you with locating a hospital, you can refine your search by selecting the country in which the hospital is located and choose to search by either hospital name, city/town or state/county.

 Home>> Protonix (pantoprazole sodium) Intravenous Formulation

Protonix (pantoprazole sodium) Intravenous Formulation

General Information

An intravenous (IV) formulation of Protonix (pantoprazole sodium) has been approved by the FDA for the short-term treatment (7 to 10 days) of gastroesophageal reflux disease (GERD) as an alternative to oral therapy in patients who are unable to continue taking Protonix Delayed-Release Tablets. Protonix IV is the first intravenous formulation available in the United States of the gastrointestinal drug class known as proton pump inhibitors. Currently, physicians use intravenous H2 antagonists to manage patients unable to take oral therapies.

Proton pump inhibitors work by targeting (H+,K+)-ATPase, an enzyme located on gastric (stomach) parietal cells. Protonix inhibits or blocks (H+,K+)-ATPase by forming a bond to two sites of the enzyme system, and as a result, suppresses the final step in gastric acid production.

GERD is a chronic condition caused by the reflux (reverse flow) of stomach acid into the esophagus. More than 40% of adults - nearly 60 million Americans - experience symptoms of GERD (typically a burning pain behind the breastbone) two or more times per week. According to an American Gastroenterology Association National survey, nearly 50 million Americans experience nighttime heartburn. If left untreated or uncontrolled, esophageal damage caused by GERD may lead to even more serious complications, including hemorrhage, Barrett's esophagus and esophageal cancer.


Additional Information

For additional information on all Protonix products, please visit Wyeth-Ayerst.

Additionally, more information on GERD can be obtained at the National Institute of Diabetes & Digestive & Kidney Diseases.


Clinical Results

Protonix has been evaluated in more than 100 trials worldwide, involving more than 45,000 subjects. Protonix IV has been used in more than 1.3 million subjects worldwide and is approved in 43 countries.


Mechanism of Action

Pantoprazole is a proton pump inhibitor that suppresses the final step in gastric acid production by forming a covalent bond to two sites of the (H+, K+)-ATPase enzyme system at the secretory surface of the gastric parietal cell. This effect is dose-related and leads to the inhibition of both basal and stimulated gastric acid secretion irrespective of the stimulus. The binding to the (H+, K+)-ATPase results in a duration of antisecretory effect that persists longer than 24 hours. (Protonix Prescribing Information)


Side effects

The most frequently reported adverse events with Protonix IV use include (but are not limited to) the following:


  • Abdominal pain
  • Chest pain
  • Rash
  • Pruritus (itching skin)

Protonix is contraindicated in patients with known hypersensitivity to any component of the formulation.

Because Protonix IV is indicated as an alternative to oral therapy for patients who are unable to continue taking the tablet form, treatment with Protonix IV should be discontinued as soon as the patient is able to be treated with Protonix Delayed-Release Tablets.


Treatment

Gastroesophageal reflux disease

Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print ProAmatine (midodrine) Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Orencia (abatacept) Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Zithromax (azithromycin) Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Peg-Intron (peginterferon alfa-2b) Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Axona (caprylidene) Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Rythmol Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Diovan (valsartan) Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Glyburide Tablets Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Bromfenac Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Promacta (eltrombopag) Vimovo (naproxen + esomeprazole) Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Zofran Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Aciphex (rabeprazole sodium) Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Amerge Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Pramipexole Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Bridion (sugammadex) Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Votrient (pazopanib) Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Rapamune (sirolimus) Tablets Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print OsmoCyte Pillow Wound Dressing Tekamlo (aliskiren + amlodipine) Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Azor (amlodipine besylate; olmesartan medoxomil) Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Lynparza (olaparib) Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Captopril and hydrochlorotiazide Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Cipro (ciprofloxacin HCl) Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Rescula (unoprostone isopropyl ophthalmic solution) 0.15% Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Boniva (ibandronate) Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Lustra Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Rapamune (sirolimus) oral solution Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Rayaldee (calcifediol) Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Bextra Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Carnexiv (carbamazepine) Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Xifaxan (rifaximin) Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Refludan Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Accolate Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Rid Mousse Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Onivyde (irinotecan liposome injection) Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Children's Motrin Cold Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Proleukin Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Altocor (lovastatin) Extended-Release Tablets Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print INFERGEN (interferon alfacon-1)