Our comprehensive guide hospitals information helps you quickly locate a hospital anywhere in the world. Our database contains in excess of 16,000 hospitals, making it one of the best places to find information on the hospital you are searching for. To assist you with locating a hospital, you can refine your search by selecting the country in which the hospital is located and choose to search by either hospital name, city/town or state/county.

 Home>> Protonix (pantoprazole sodium) Intravenous Formulation

Protonix (pantoprazole sodium) Intravenous Formulation

General Information

An intravenous (IV) formulation of Protonix (pantoprazole sodium) has been approved by the FDA for the short-term treatment (7 to 10 days) of gastroesophageal reflux disease (GERD) as an alternative to oral therapy in patients who are unable to continue taking Protonix Delayed-Release Tablets. Protonix IV is the first intravenous formulation available in the United States of the gastrointestinal drug class known as proton pump inhibitors. Currently, physicians use intravenous H2 antagonists to manage patients unable to take oral therapies.

Proton pump inhibitors work by targeting (H+,K+)-ATPase, an enzyme located on gastric (stomach) parietal cells. Protonix inhibits or blocks (H+,K+)-ATPase by forming a bond to two sites of the enzyme system, and as a result, suppresses the final step in gastric acid production.

GERD is a chronic condition caused by the reflux (reverse flow) of stomach acid into the esophagus. More than 40% of adults - nearly 60 million Americans - experience symptoms of GERD (typically a burning pain behind the breastbone) two or more times per week. According to an American Gastroenterology Association National survey, nearly 50 million Americans experience nighttime heartburn. If left untreated or uncontrolled, esophageal damage caused by GERD may lead to even more serious complications, including hemorrhage, Barrett's esophagus and esophageal cancer.


Additional Information

For additional information on all Protonix products, please visit Wyeth-Ayerst.

Additionally, more information on GERD can be obtained at the National Institute of Diabetes & Digestive & Kidney Diseases.


Clinical Results

Protonix has been evaluated in more than 100 trials worldwide, involving more than 45,000 subjects. Protonix IV has been used in more than 1.3 million subjects worldwide and is approved in 43 countries.


Mechanism of Action

Pantoprazole is a proton pump inhibitor that suppresses the final step in gastric acid production by forming a covalent bond to two sites of the (H+, K+)-ATPase enzyme system at the secretory surface of the gastric parietal cell. This effect is dose-related and leads to the inhibition of both basal and stimulated gastric acid secretion irrespective of the stimulus. The binding to the (H+, K+)-ATPase results in a duration of antisecretory effect that persists longer than 24 hours. (Protonix Prescribing Information)


Side effects

The most frequently reported adverse events with Protonix IV use include (but are not limited to) the following:


  • Abdominal pain
  • Chest pain
  • Rash
  • Pruritus (itching skin)

Protonix is contraindicated in patients with known hypersensitivity to any component of the formulation.

Because Protonix IV is indicated as an alternative to oral therapy for patients who are unable to continue taking the tablet form, treatment with Protonix IV should be discontinued as soon as the patient is able to be treated with Protonix Delayed-Release Tablets.


Treatment

Gastroesophageal reflux disease

Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Rayaldee (calcifediol) Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Omontys (peginesatide) Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Oralair (Sweet Vernal, Orchard, Perennial Rye, Timothy and Kentucky Blue Grass Mixed Pollens Allergen Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Rayos (prednisone) delayed-release tablets Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Diovan (valsartan) Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Qsymia (phentermine + topiramate extended-release) Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Afstyla (Antihemophilic Factor (Recombinant), Single Chain) Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Vonvendi [von Willebrand factor (Recombinant)] Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Remicade (infliximab) Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Pravachol (pravastatin sodium) Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Olysio (simeprevir) Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Paxil (paroxetine hydrochloride) Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Caduet (amlodipine/atorvastatin) Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Otiprio (ciprofloxacin otic suspension) Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Afinitor (everolimus) Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Promacta (eltrombopag) Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Infasurf Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Bio-T-Gel (testosterone gel) Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Oxytrol (oxybutynin transdermal system) Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print INFERGEN (interferon alfacon-1) Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Akynzeo (netupitant and palonosetron) Amturnide (aliskiren + amlodipine + hydrochlorothiazide) Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Zoloft (sertraline HCl) Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Onfi (clobazam) Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Chloraprep (chlorhexidine gluconate) Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Prandin Tekamlo (aliskiren + amlodipine) Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Adderall XR Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Campath Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Osphena (ospemifene) Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Fycompa (perampanel) Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Monistat 3 (miconazole nitrate) Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Dynabac Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Reyataz (atazanavir sulfate) Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Panretin Gel Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Clarinex Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Amevive (alefacept) Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Xifaxan (rifaximin) Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Alimta (pemetrexed for injection) Tribenzor (olmesartan medoxomil + amlodipine + hydrochlorothiazide)