Our comprehensive guide hospitals information helps you quickly locate a hospital anywhere in the world. Our database contains in excess of 16,000 hospitals, making it one of the best places to find information on the hospital you are searching for. To assist you with locating a hospital, you can refine your search by selecting the country in which the hospital is located and choose to search by either hospital name, city/town or state/county.

 Home>> Sklice (ivermectin) lotion

Sklice (ivermectin) lotion

General Information

Ivermectin is a broad-spectrum antiparasitic agent that binds selectively to certain ion channels in invertebrate nerve and muscle cells. This leads to an increase in the permeability of the cell membrane, resulting in paralysis and death of the parasite.

Sklice is specifically indicated for the topical treatment of head lice infestations in patients six months of age and older.

Sklice is supplied as a lotion for topical treatment. Sklice should be applied to dry hair in an amount sufficient (up to one tube) to thoroughly coat the scalp and hair. Leave Sklice on the hair and scalp for 10 minutes and then rinse off with water.


Additional Information

For additional information regarding Sklice or head lice, please visit the products.sanofi.us web page.


Clinical Results

FDA Approval
The FDA approval of Sklice was based on two phase III trials. A total of 781 subjects ages six months and older were treated with 0.5% ivermectin cream or placebo applied to dry hair and scalp, followed by a rinsing after 10 minutes. A nit comb was not used. The primary efficacy endpoint was the proportion of subjects who were free of live lice at day 2 and through day 8 to the final evaluation 14 days following a single application. Significantly more subjects in the Sklice Lotion group were louse-free compared to the placebo group: 76% in Study 1 and 71% in Study 2. Sklice was well-tolerated and the majority of Sklice-treated patients were lice-free without any nit combing after two weeks. Fewer than 1% of subjects experienced adverse events.


Mechanism of Action

Sklice Lotion contains a broad-spectrum antiparasitic agent, ivermectin, which was developed from a soil bacterium that produces a family of compounds (avermectins) shown to bind selectively and with high affinity to certain ion channels present in invertebrate nerve and muscle cells but not in mammals. The resulting increased permeability of the cell membrane causes paralysis and death in certain parasites.


Side effects

Adverse events associated with the use of Sklice may include, but are not limited to, the following:

  • conjunctivitis
  • ocular hyperemia
  • eye irritation
  • dandruff
  • dry skin
  • skin burning sensation


Treatment

head lice

Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Imitrex (sumatriptan) nasal spray Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Nuplazid (pimavanserin) Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Ultracet (acetaminophen and tramadol HCl) Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Remodulin (treprostinil) Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Cabometyx (cabozantinib) Jalyn (dutasteride + tamsulosin) Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Clolar (clofarabine) Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Aciphex (rabeprazole sodium) Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Adempas (riociguat) Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Atracurium Besylate Injection Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Ruconest (C1 esterase inhibitor [recombinant]) Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Campath Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Livalo (pitavastatin) Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Trovan Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Requip (ropinirole hydrochloride) Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Prempro Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Remeron SolTab (mirtazapine) Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Rid Mousse Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Vpriv (velaglucerase alfa for injection) Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Teczem (enalapril maleate/diltiazem malate) Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print AneuVysion Assay Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Plenaxis (abarelix for injectable suspension) Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Perjeta (pertuzumab) Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Repatha (evolocumab) Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Addyi (flibanserin) Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Valstar Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Qvar (beclomethasone dipropionate) Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Amerge Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Paxil (paroxetine hydrochloride) Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Pindolol Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Argatroban Injection Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Betapace AF Tablet Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Adderall (mixed salts of a single-entity amphetamine) Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Protonix (pantoprazole sodium) Delayed-Release Tablets Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Abilify (aripiprazole) Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Panretin Gel Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print ReoPro Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Bio-T-Gel (testosterone gel) Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Akynzeo (netupitant and palonosetron) Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Rapamune (sirolimus) Tablets