Our comprehensive guide hospitals information helps you quickly locate a hospital anywhere in the world. Our database contains in excess of 16,000 hospitals, making it one of the best places to find information on the hospital you are searching for. To assist you with locating a hospital, you can refine your search by selecting the country in which the hospital is located and choose to search by either hospital name, city/town or state/county.

 Home>> Subutex/Suboxone (buprenorphine/naloxone)

Subutex/Suboxone (buprenorphine/naloxone)

General Information

Subutex/Suboxone combination of two currently marketed medications, buprenorphine and naloxone. It will be used for the treatment of subjects with heroin and opiate addictions. Suboxone and Subutex were the first therapies approved for in-office prescribing under the federal Drug Addiction Treatment Act of 2000.

Suboxone and Subutex are prescribed in 2mg and 8mg oral tablets.

These products were developed under a Cooperative Research and Development Agreement between Reckitt Benckiser and the National Institutes of Health???s National Institute on Drug Abuse in the USA. Subutex first received marketing approval in France and was launched in February 1996 by Schering-Plough under licence from Reckitt Benckiser.


Additional Information

For more information on Subutex & Suboxone, please visit The Suboxone Web Site

For more information on Reckitt Benckiser please visit www.reckittbenckiser.com


Clinical Results

Suboxone tablets have been studied in 575 patients, Subutex tablets in 1834 patients and buprenorphine sublingual solutions in 2470 patients. A total of 1270 females have received buprenorphine in clinical trials. Dosing recommendations are based on data from one trial of both tablet formulations and two trials of the ethanolic solution. All trials used buprenorphine in conjunction with psychosocial counseling as part of a comprehensive addiction treatment program. There have been no clinical studies conducted to assess the efficacy of buprenorphine as the only component of treatment.

In a double blind placebo- and active controlled study, 326 heroin-addicted subjects were randomly assigned to either Suboxone 16 mg per day, 16 mg Subutex per day or placebo tablets. The primary study comparison was to assess the efficacy of Subutex and Suboxone individually against placebo. The percentage of thrice-weekly urine samples that were negative for non-study opioids was statistically higher for both Subutex and Suboxone, than for placebo.


Mechanism of Action

Suboxone offers a combination of a weak narcotic (buprenorphine) and a narcotic antagonist (naloxone). The latter is added to prevent addicts from injecting the tablets intravenously, as has happened with tablets only containing buprenorphine; because it contains naloxone, Suboxone is highly likely to produce intense withdrawal symptoms if misused intravenously by opioid-addicted individuals.

Buprenorphine is a partial agonist at the mu-opioid receptor and an antagonist at the kappaopioid receptor. Naloxone is an antagonist at the mu-opioid receptor.


Side effects

Adverse events associated with the use of Suboxone and Subutex may include (but are not limited to) the following:

  • Asthenia
  • Headache
  • Pain
  • Constipation
  • Nausea
  • Insomnia
  • Withdrawl Syndrome
  • Sweating
  • Chills
  • Rhinitis
  • Infection

Treatment

Opiate Dependence

Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Rozerem (ramelteon) Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Prezista (darunavir) Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Altocor (lovastatin) Extended-Release Tablets Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Byvalson (nebivolol and valsartan) Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Rituxan Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Altabax (retapamulin) Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Amrix (cyclobenzaprine hydrochloride extended release) Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Ragwitek (Short Ragweed Pollen Allergen Extract) Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Bextra Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Olysio (simeprevir) Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Betapace AF Tablet Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Omontys (peginesatide) Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Corlanor (ivabradine) Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Pancreaze (pancrelipase) Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Proscar Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Teczem (enalapril maleate/diltiazem malate) Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Actemra (tocilizumab) Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Reminyl (galantamine hydrobromide) Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Prolia (denosumab) Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Letairis (ambrisentan) Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Panretin Gel Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Adderall (mixed salts of a single-entity amphetamine) Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Alrex Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Retin-A Micro (tretinoin gel) microsphere, 0.1% Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Prilosec (omeprazole)/Biaxin (clarithromycin) Combination Therapy Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Biaxin XL (clarithromycin extended-release tablets) Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Rayos (prednisone) delayed-release tablets Dulera (mometasone furoate + formoterol fumarate dihydrate) Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Orencia (abatacept) Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Arranon (nelarabine) Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Photodynamic Therapy Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Praluent (alirocumab) Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Clarinex Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Opdivo (nivolumab) Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Aptivus (tipranavir) Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Nuplazid (pimavanserin) Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Patanase (olopatadine hydrochloride) Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Bridion (sugammadex) Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Photofrin Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Diovan (valsartan)