Our comprehensive guide hospitals information helps you quickly locate a hospital anywhere in the world. Our database contains in excess of 16,000 hospitals, making it one of the best places to find information on the hospital you are searching for. To assist you with locating a hospital, you can refine your search by selecting the country in which the hospital is located and choose to search by either hospital name, city/town or state/county.

 Home>> Travatan (travoprost ophthalmic solution)

Travatan (travoprost ophthalmic solution)

General Information

Travatan has been approved by the FDA for the reduction of elevated intraocular pressure (IOP) in patients with open-angle glaucoma or ocular hypertension. It is indicated for patients who are intolerant of or insufficiently responsive to other intraocular pressure lowering medications.

Travoprost, the active ingredient in Travatan, is a synthetic prostaglandin analogue. It targets the prostanoid receptor and is believed to reduce intraocular pressure by increasing the drainage of fluid (aqueous humor) from the eye.

There are approximately two to three million individuals in the United States with glaucoma, a condition often associated with elevated intraocular pressure leading to optic nerve damage. Glaucoma is a leading cause of blindness, accounting for approximately 12% of all new cases in the United States each year. While glaucoma significantly affects all races and ages, it appears to particularly target individuals of African descent, appearing at an earlier age and progressing at a more rapid rate. Travatan, unlike other glaucoma treatments, has demonstrated greater effectiveness in African-American patients.


Additional Information

Travatan should not be administered while wearing contact lenses - the drug contains benzalkonium chloride, which may be absorbed by the lens. Additionally, contact between the tip of the container and the eye or surrounding area should be avoided when administering Travatan. This contact could cause the tip to become contaminated and result in ocular infection.

If you are interested in learning more about glaucoma, please visit the National Institutes of Health, National Eye Institute.

Additional information on Travatan can be obtained by visiting Alcon.


Clinical Results

Trial results demonstrated that subjects with open-angle glaucoma or ocular hypertension who were treated with Travatan Ophthalmic Solution 0.004% experienced 7-8 mm Hg reductions in intraocular pressure. Subjects had a baseline pressure of 25-27 mm Hg and were dosed once-daily in the evening. Subgroup analyses of these trials showed that mean IOP reduction in African-American subjects was up to 1.8 mm Hg greater than in non-African-American subjects. At this time, it is not known whether this difference is due to race or to heavily pigmented irides.

A multicenter, randomized, controlled trial evaluated the efficacy of Travatan dosed adjunctively to Timoptic. Results showed that subjects with a mean baseline intraocular pressure of 24-26 mm Hg on Timoptic 0.5% BID who were treated with Travatan 0.004% dosed QD adjunctively to Timoptic 0.5% BID demonstrated 6-7 mm Hg reductions in intraocular pressure.


Mechanism of Action

Travoprost free acid is a selective FP prostanoid receptor agonist which is believed to reduce intraocular pressure by increasing uveoscleral outflow. The exact mechanism of action is unknown at this time. (from Travatan Label)


Side effects

The use of Travatan has been associated with possibly permanent changes in pigmented tissues, including increased pigmentation of the iris and periorbital tissue (eyelid) and increased pigmentation and growth of eyelashes.

The most common eye-related adverse event reported in clinical trials was ocular hyperemia, which was reported in 35 to 50% of subjects. Other events included (but are not limited to) the following:

  • Decreased visual acuity
  • Eye discomfort
  • Foreign body sensation
  • Pain
  • Pruritus

Treatment

Glaucoma or ocular hypertension

Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Amturnide (aliskiren + amlodipine + hydrochlorothiazide) Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Carnexiv (carbamazepine) Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Xifaxan (rifaximin) Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Auryxia (Ferric citrate) Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Reclast (zoledronic acid) Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Glyburide Tablets Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Agrylin (anagrelide HCL) Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Cipro (ciprofloxacin HCl) Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Prandin Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Aptivus (tipranavir) Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Revlimid (lenalidomide) Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Votrient (pazopanib) Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Cetrotide Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Renvela (sevelamer carbonate) Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Quillivant XR (methylphenidate hydrochloride) Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Paxil (paroxetine hydrochloride) Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Cambia (diclofenac potassium for oral solution) Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Galzin (zinc acetate) Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Prinivil or Zestril (Lisinopril) Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Procysbi (cysteamine bitartrate) Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Praluent (alirocumab) Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Oxycodone and Aspirin Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Plavix (clopidogrel bisulfate) Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Pradaxa (dabigatran etexilate mesylate) Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Remodulin (treprostinil) Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Abilify (aripiprazole) Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Rilutek (riluzole) Qsymia (phentermine + topiramate extended-release) Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print AneuVysion Assay Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Actemra (tocilizumab) Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Ortho Tri-Cyclen Tablets (norgestimate/ethinyl estradiol) Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Aromasin Tablets Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Vpriv (velaglucerase alfa for injection) Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Peg-Intron (peginterferon alfa-2b) Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Acular (ketorolac tromethamine ophthalmic solution) 0.5% Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Oxtellar XR (oxcarbazepine extended release) Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Mircette Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Adcirca (tadalafil) Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Rytary (carbidopa and levodopa) extended-release capsules Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Protopic (tacrolimus) ointment