Our comprehensive guide hospitals information helps you quickly locate a hospital anywhere in the world. Our database contains in excess of 16,000 hospitals, making it one of the best places to find information on the hospital you are searching for. To assist you with locating a hospital, you can refine your search by selecting the country in which the hospital is located and choose to search by either hospital name, city/town or state/county.

 Home>> UroXatral (alfuzosin HCl extended-release tablets)

UroXatral (alfuzosin HCl extended-release tablets)

General Information

UroXatral (alfuzosin HCl extended-release) tablets belongs to a class of drugs called alpha-blockers. It is used in adult men to treat the symptoms of benign prostatic hyperplasia (BPH). UroXatral may help to relax the muscles in the prostate and the bladder, which may lessen the symptoms of BPH and improve urine flow.

UroXatral is indicated for the treatment of the signs and symptoms of benign prostatic hyperplasia. This drug is not indicated for the treatment of hypertension.

The active ingredient, alfuzosin, is marketed in more than 80 countries throughout Europe, Latin America, Africa and Asia. Outside of the United States, the once-daily formulation (Xatral OD) is registered in 70 countries worldwide; it is currently marketed in 14 countries in Europe and in more than 35 other countries.


Additional Information

For additional information regarding UroXatral or benign prostatic hyperplasia, please contact The Sanofi-Synth??labo Web Site


Clinical Results

FDA approval is based on three randomized placebo-controlled, double-blind, parallel-arm, 12-week studies. The studies enrolled 1,608 subjects of which 473 subjects received UroXatral 10 mg daily. The pharmacokinetics of UroXatral have been evaluated in adult healthy male volunteers after single and/or multiple administration with daily doses ranging from 7.5 mg to 30 mg, and in patients with BPH at doses from 7.5 mg to 15 mg.

The International Prostate Symptom Score (IPSS, or AUA Symptom Score) consists of seven questions that assess the severity of both irritative (frequency, urgency, nocturia) and obstructive (incomplete emptying, stopping and starting, weak stream, and pushing or straining) symptoms, with possible scores ranging from 0 to 35. Results showed a statistically significant reduction from baseline to last assessment (Week 12) in the IPSS versus placebo in all three studies, indicating a reduction in symptom severity. The second efficacy variable was peak urinary flow rate. Peak urinary flow rate increased statistically significantly from baseline to last assessment (Week 12) versus placebo in studies 1 and 2. Mean total IPSS decreased at the first scheduled observation at Day 28 and mean peak flow rate increased starting at the first scheduled observation at Day 14 in studies 2 and 3 and Day 28 in study 1.


Mechanism of Action

UroXatral (alfuzosin HCl extended-release) is a selective antagonist of post-synaptic alpha1-adrenoreceptors, which are located in the prostate, bladder base, bladder neck, prostatic capsule and prostatic urethra. Blockade of these adrenoreceptors can cause smooth muscle in the bladder neck and prostate to relax, resulting in an improvement in urine flow and a reduction in symptoms of BPH.


Literature References

Side effects

Adverse events associated with the use of UroXatral may include (but are not limited to) the following:


  • Upper respiratory tract infection
  • Headache
  • Fatigue
  • Pain
  • Impotence

Treatment

Benign Prostatic Hyperplasia

Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Rozerem (ramelteon) Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Adcetris (brentuximab vedotin) Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Arimidex (anastrozole) Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Rexulti (brexpiprazole) Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Injectafer (ferric carboxymaltose injection) Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Protonix (pantoprazole sodium) Delayed-Release Tablets Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Rhinocort Aqua Nasal Spray Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Anzemet Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print laViv (azficel-T) Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print REBETRON (TM) Combination Therapy Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Bridion (sugammadex) Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Pepcid Complete Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Argatroban Injection Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Corlanor (ivabradine) Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Crestor (rosuvastatin calcium) Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Rebif (interferon beta-1a) Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print OxyContin (oxycodone HCl controlled-release) Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Pravachol (pravastatin sodium) Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Cetrotide Qsymia (phentermine + topiramate extended-release) Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Ruconest (C1 esterase inhibitor [recombinant]) Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Trovan Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Pancreaze (pancrelipase) Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Claritin-D 24 Hour Extended Release Tablets (10 mg loratadine, 240 mg pseudoephedrine sulfate) Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Ritalin LA (methylphenidate HCl) Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Plegridy (peginterferon beta-1a) Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Carnexiv (carbamazepine) Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print RespiGam (Respiratory Syncitial Virus Immune Globulin Intravenous) Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Cipro (ciprofloxacin HCl) Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Ultracet (acetaminophen and tramadol HCl) Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Afstyla (Antihemophilic Factor (Recombinant), Single Chain) Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Qnasl (beclomethasone dipropionate) nasal aerosol Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Alphagan (brimonidine) Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Prevnar 13 (Pneumococcal 13-valent Conjugate Vaccine) Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Prograf Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Acuvail (ketorolac tromethamine) Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Makena (hydroxyprogesterone caproate injection) Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Omidria (phenylephrine and ketorolac injection) Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Rotateq (rotavirus vaccine, live oral pentavalent) Select an option ICD-9 and ICD-10 ICD-9CM ICD-10CM Back News | Share | Print Pulmozyme (dornase alfa)